HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients
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چکیده
منابع مشابه
HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients
BACKGROUND A high incidence of rash has been reported in HIV-1 patients who received the anti-retroviral drug nevirapine. In addition, several studies have suggested that polymorphisms of human leukocyte antigen (HLA) genes may play important roles in nevirapine-induced rash. The aim of the present study was to evaluate the effects of different HLA-C alleles on rash associated with nevirapine i...
متن کاملAssociation of Nevirapine Levels with Rash or Hepatotoxicity Among HIV-Infected Thai Women
BACKGROUND We performed a nested case-control study of Thai women prescribed nevirapine-based antiretroviral therapy (ART) to determine if development of rash or hepatotoxicity during the first 24 weeks of treatment is associated with plasma nevirapine concentrations. METHOD From May 2005-January 2007, we enrolled 217 women initiating nevirapine-based ART in Thailand. Cases (n = 54) were wome...
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BACKGROUND Nevirapine-based antiretroviral therapy is widely used as a first-line treatment for HIV-infected patients in resource-limited settings. Nevirapine plasma concentration has been shown to be associated with virological response and treatment failure. Therefore, identifying sources of the variability of nevirapine pharmacokinetics is important for dose optimization. The purpose of the ...
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*Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Tiwanon Road, Nonthaburi 11000, Thailand. **Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. Received for publication: October 2, 2006. Reprint request: Weerawat Manosuthi, M.D., Department of Medicine, Bamrasnaradura Infectious Di...
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Objective(s): This study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China).Materials and Methods: Polymerase chain reaction-sequence specific primers were used to detect HLA-Cw01–08 of 201 RA patients an...
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ژورنال
عنوان ژورنال: AIDS Research and Therapy
سال: 2009
ISSN: 1742-6405
DOI: 10.1186/1742-6405-6-22